Research

We aim to understand how viruses breach the body’s key cellular barriers and establish infection, with a particular focus on the mechanisms underlying viral pathogenesis. In parallel, we work to translate these insights into more effective strategies for prevention and treatment. Our research focuses on three critical biological interfaces that play central roles in viral disease: the respiratory tract, the central nervous system, and the maternal-fetal barrier. These sites represent major points of entry, dissemination, and vulnerability, especially for viruses with significant impact on human and animal health.

Using a combination of advanced experimental systems, including primary cells, organoids, tissue explants, and in vivo models, we investigate how viruses interact with host cells at these interfaces. Our work seeks to elucidate the mechanisms governing viral entry, cell and tissue tropism, and the dysregulation of host responses and resulting virus-induced damage. Ultimately, our goal is to contribute to better protection of vulnerable populations and to strengthen preparedness against emerging and re-emerging viral threats.