Publications 2021 (IVI)

Agerer, B., Koblischke, M., Gudipati, V., Montaño-Gutierrez, L.F., Smyth, M., Popa, A., Genger, J.W., Endler, L., Florian, D.M., Mühlgrabner, V., Graninger, M., Aberle, S.W., Husa, A.M., Shaw, L.E., Lercher, A., Gattinger, P., Torralba-Gombau, R., Trapin, D., Penz, T., Barreca, D., Fae, I., Wenda, S., Traugott, M., Walder, G., Pickl, W.F., Thiel, V., Allerberger, F., Stockinger, H., Puchhammer-Stöckl, E., Weninger, W., Fischer, G., Hoepler, W., Pawelka, E., Zoufaly, A., Valenta, R., Bock, C., Paster, W., Geyeregger, R., Farlik, M., Halbritter, F., Huppa, J.B., Aberle, J.H., and Bergthaler, A. (2021) SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses. Science Immunology 6:57, eabg6461. (PubMed) (article)

Asín, J., Hilbe, M., de Miguel, R., Rodríguez-Largo, A., Lanau, A., Akerman, A., Stalder, H.P., Schweizer, M., and Luján, L. (2021) An outbreak of abortions, stillbirths, and malformations in a Spanish sheep flock associated with a bovine viral diarrhea virus 2-contaminated orf vaccine. Transboundary and Emerging Diseases 68:2, 233-239. (PubMed) (article)

Ayrle, H., Mevissen, M., Bruckmaier, R.M., Wellnitz, O., Kaske, M., Bieber, A., Vögtlin, A., Fricker, R., and Walkenhorst, M. (2021) Effects of an oral hydro-ethanolic purple coneflower extract on performance, clinical health and immune parameters in calves. Research in Veterinary Science 138, 148-160. (PubMed) (article)

Bhatt, P.R., Scaiola, A., Loughran, G., Leibundgut, M., Kratzel, A.#, Meurs, R., Dreos, R., O’Connor, K.M., McMillan, A., Bode, J.W., Thiel, V., Gatfield, D., Atkins, J.F., and Ban, N. (2021) Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science 372:6548, 1306-1313. (PubMed) (article)

Brigger, D., Horn, M.P., Pennington, L.F., Powell, A.E., Siegrist, D., Weber, B., Engler, O., Piezzi, V., Damonti, L., Iseli, P., Hauser, C., Froehlich, T.K., Villiger, P.M., Bachmann, M.F., Leib, S.L., Bittel, P., Fiedler, M., Largiadèr, C., Marschall, J., Stalder, H., Kim, P.S., Jardetzky, T.S., Eggel, A., and Nagler, M. (2021) Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study. Allergy 76:3, 853-865. (PubMed) (article)

Brügger, M.#, Démoulins, T., Barut, G.T., Zumkehr, B., Oliveira Esteves, B.I., Mehinagic, K.#, Haas, Q., Schögler, A., Rameix-Welti, M.A., Eléouët, J.F., Moehrlen, U., Marti, T.M., Schmid, R.A., Summerfield, A., Posthaus, H., Ruggli, N., Hall, S.R.R., and Alves, M.P. (2021) Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS Pathogens 17:7, e1009789 (in press). (PubMed) (article)

Démoulins, T., Brügger, M.#, Zumkehr, B., Oliveira Esteves, B.I., Mehinagic, K.#, Fahmi, A., Borcard, L.#, Taddeo, A., Jandrasits, D., Posthaus, H., Benarafa, C., Ruggli, N., and Alves, M.P. (2021) The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis. PLoS Pathogens 17:4, e1009529. (PubMed) (article)

Démoulins, T., Ruggli, N., Gerber, M., Thomann-Harwood, L.J., Ebensen, T., Schulze, K., Guzmán, C.A., and McCullough, K.C. (2021) Self-amplifying pestivirus replicon RNA encoding influenza virus nucleoprotein and hemagglutinin promote humoral and cellular immune responses in pigs. Frontiers in Immunology 11, 622385. (PubMed) (article)

García-Nicolás, O., V'kovski, P., Zettl, F., Zimmer, G., Thiel, V., and Summerfield, A. (2021) No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection. Frontiers in Cellular and Infection Microbiology 11, 644574. (PubMed) (article)

Germic, N., Hosseini, A., Stojkov, D., Oberson, K., Claus, M., Benarafa, C., Calzavarini, S., Angelillo-Scherrer, A., Arnold, I.C., Müller, A., Riether, C., Yousefi, S., and Simon, H.U. (2021) ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions. Blood 137:21, 2958-2969. (PubMed) (article)

Gultom, M., Licheri, M., Laloli, L., Wider, M., Strässle, M., V'kovski, P., Steiner, S., Kratzel, A., Thao, T.T.N., Probst, L., Stalder, H., Portmann, J., Holwerda, M., Ebert, N., Stokar-Regenscheit, N., Gurtner, C., Zanolari, P., Posthaus, H., Schuller, S., Vicente-Santos, A., Moreira-Soto, A., Corrales-Aguilar, E., Ruggli, N., Tekes, G., von Messling, V., Sawatsky, B., Thiel, V., and Dijkman, R. (2021) Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wild animals to severe acute respiratory syndrome coronavirus 2. Emerging Infectious Diseases 27:7, 1811-1820. (PubMed) (article)

Holwerda, M.#, Laloli, L.#, Wider, M., Schönecker, L., Becker, J., Meylan, M., and Dijkman, R. (2021) Establishment of a reverse genetic system from a bovine derived influenza D virus isolate. Viruses-Basel 13:3, 502. (PubMed) (article)

Klaus, J., Meli, M.L., Willi, B., Nadeau, S., Beisel, C., Stadler, T., ETH SARS-CoV-2 Sequencing Team, Egberink, H., Zhao, S., Lutz, H., Riond, B., Rösinger, N., Stalder, H., Renzullo, S., and Hofmann-Lehmann, R. (2021) Detection and genome sequencing of SARS-CoV-2 in a domestic cat with respiratory signs in Switzerland. Viruses-Basel 13:3, 496. (PubMed) (article)

Konings, F., Perkins, M.D., Kuhn, J.H., Pallen, M.J., Alm, E.J., Archer, B.N., Barakat, A., Bedford, T., Bhiman, J.N., Caly, L., Carter, L.L., Cullinane, A., de Oliveira, T., Druce, J., El Masry, I., Evans, R., Gao, G.F., Gorbalenya, A.E., Hamblion, E., Herring, B.L., Hodcroft, E., Holmes, E.C., Kakkar, M., Khare, S., Koopmans, M.P.G., Korber, B., Leite, J., MacCannell, D., Marklewitz, M., Maurer-Stroh, S., Rico, J.A.M., Munster, V.J., Neher, R., Munnink, B.O., Pavlin, B.I., Peiris, M., Poon, L., Pybus, O., Rambaut, A., Resende, P., Subissi, L., Thiel, V., Tong, S., van der Werf, S., von Gottberg, A., Ziebuhr, J., and Van Kerkhove, M.D. (2021) SARS-CoV-2 Variants of Interest and Concern naming scheme conducive for global discourse. Nature Microbiology 6:7, 821-823. (PubMed) (article)

Lechmann, J., Ackermann, M., Kaiser, V., and Bachofen, C. (2021) Viral infections shared between water buffaloes and small ruminants in Switzerland. Journal of Veterinary Diagnostic Investigation, in press. (PubMed) (article)

Lei, J., Ma-Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., Thiel, V., Beckmann, R., Deng, W., Leonhardt, H., Hilgenfeld, R., and von Brunn, A. (2021) The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. EMBO Journal 40:11, e102277. (PubMed) (article)

Letko, A., Bützberger, C., Hirter, N., Paris, J.M., Abril, C., and Drögemüller, C. (2021) Genetic evaluation of small ruminant lentivirus susceptibility in Valais blacknose sheep. Animal Genetics, in press. (PubMed) (article)

Maes, D., Boyen, F., Devriendt, B., Kuhnert, P., Summerfield, A., and Haesebrouck, F. (2021) Perspectives for improvement of Mycoplasma hyopneumoniae vaccines in pigs. Veterinary Research 52:1, 67. (PubMed) (article)

Meurens, F., Dunoyer, C., Fourichon, C., Gerdts, V., Haddad, N., Kortekaas, J., Lewandowska, M., Monchatre-Leroy, E., Summerfield, A., Wichgers Schreur, P.J., van der Poel, W.H.M., and Zhu, J. (2021) Animal board invited review: Risks of zoonotic disease emergence at the interface of wildlife and livestock systems. Animal 15:6, 100241. (PubMed) (article)

Picotto, L.D., Fuentealba, N.A., Bertoni, G., Patrucco, M., Sguazza, G.H., Echeverria, M.G., and Panei, C.J. (2021) Argentinian small ruminant lentivirus (SRLV) p55gag antigen fused to maltose binding protein to use in SRLV serological confirmatory diagnosis. Virus Research 296, 198332. (PubMed) (article)

Ries, C., Vögtlin, A., Hüssy, D., Jandt, T., Gobet, H., Hilbe, M., Burgener, C., Schweizer, L., Häfliger-Speiser, S., Beer, M., and Hoffmann, B. (2021) Putative novel atypical BTV serotype '36' identified in small ruminants in Switzerland. Viruses-Basel 13:5, 721. (PubMed) (article)

Schijns, V., Majhen, D., van der Ley, P., Thakur, A., Summerfield, A., Berisio, R., Nativi, C., Fernández-Tejada, A., Alvarez-Dominguez, C., Gizurarson, S., Zamyatina, A., Molinaro, A., Rosano, C., Jakopin, Ž., Gursel, I., and McClean, S. (2021) Rational vaccine design in times of emerging diseases: the critical choices of immunological correlates of protection, vaccine antigen and immunomodulation. Pharmaceutics 13:4, 501. (PubMed) (article)

Stevaert, A., Krasniqi, B., Van Loy, B., Nguyen, T., Thomas, J., Vandeput, J., Jochmans, D., Thiel, V., Dijkman, R., Dehaen, W., Voet, A., and Naesens, L. (2021) Betulonic acid derivatives interfering with human coronavirus 229E replication via the nsp15 endoribonuclease. Journal of Medicinal Chemistry 64:9, 5632-5644. (PubMed) (article)

Strässle, M., Laloli, L.#, Gultom, M.#, V'kovski, P., Stoffel, M.H., Crespo Pomar, S., Chanfon Bätzner, A., Ebert, N., Labroussaa, F., Dijkman, R., Jores, J., and Thiel, V. (2021) Establishment of caprine airway epithelial cells grown in an air-liquid interface system to study caprine respiratory viruses and bacteria. Veterinary Microbiology 257, 109067. (PubMed) (article)

Studer, E., Schönecker, L., Meylan, M., Stucki, D., Dijkman, R., Holwerda, M.#, Glaus, A., and Becker, J. (2021) Prevalence of BRD-related viral pathogens in the upper respiratory tract of Swiss veal calves. Animals (Basel) 11:7, 1940. (PubMed) (article)

Stukalov, A., Girault, V., Grass, V., Karayel, O., Bergant, V., Urban, C., Haas, D.A., Huang, Y., Oubraham, L., Wang, A., Hamad, M.S., Piras, A., Hansen, F.M., Tanzer, M.C., Paron, I., Zinzula, L., Enghleitner, T., Reinecke, M., Lavacca, T.M., Ehmann, R., Wölfel, R., Jores, J., Kuster, B., Protzer, U., Rad, R., Ziebuhr, J., Thiel, V., Scaturro, P., Mann, M., and Pichlmair, A. (2021) Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 594:7862, 246-252. (PubMed) (article)

Tavares-Gomes, L., Monney, C., Neuhaus, G., Francisco, D.#, Solis, D., Summerfield, A., Erny, D., Jagannathan, V., and Oevermann, A. (2021) Transcriptome of microglia reveals a species-specific expression profile in bovines with conserved and new signature genes. Glia 69:8, 1932-1949. (PubMed) (article)

Trimpert, J., Dietert, K., Firsching, T.C., Ebert, N., Thao, T.T.N.#, Vladimirova, D., Kaufer, S., Labroussaa, F., Abdelgawad, A., Conradie, A., Höfler, T., Adler, J.M., Bertzbach, L.D., Jores, J., Gruber, A.D., Thiel, V., Osterrieder, N., and Kunec, D. (2021) Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding. Cell Reports 36, 109493 (in press). (PubMed) (article)

V'kovski, P., Gultom, M.#, Kelly, J.N., Steiner, S.#, Russeil, J., Mangeat, B., Cora, E., Pezoldt, J., Holwerda, M.#, Kratzel, A.#, Laloli, L.#, Wider, M., Portmann, J., Tran, T.#, Ebert, N., Stalder, H., Hartmann, R., Gardeux, V., Alpern, D., Deplancke, B., Thiel, V., and Dijkman, R. (2021) Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium. PLoS Biology 19:3, e3001158. (PubMed) (article)

V'Kovski, P., Kratzel, A.#, Steiner, S.#, Stalder, H., and Thiel, V. (2021) Coronavirus biology and replication: implications for SARS-CoV-2. Nature Reviews Microbiology 19, 155-170. (PubMed) (article)

Welner, S., Ruggli, N., Liniger, M., Summerfield, A., Larsen, L.E., and Jungersen, G. (2021) Reduced virus load in lungs of pigs challenged with porcine reproductive and respiratory syndrome virus after vaccination with virus replicon particles encoding conserved PRRSV cytotoxic T-cell epitopes. Vaccines (Basel) 9:3, 208. (PubMed) (article)

Zhou, B., Thao, T.T.N.#, Hoffmann, D., Taddeo, A., Ebert, N., Labroussaa, F., Pohlmann, A., King, J., Steiner, S.#, Kelly, J.N., Portmann, J., Halwe, N.J., Ulrich, L., Trüeb, B.S., Fan, X., Hoffmann, B., Wang, L., Thomann, L., Lin, X., Stalder, H.P., Pozzi, B., de Brot, S., Jiang, N., Cui, D., Hossain, J., Wilson, M., Keller, M., Stark, T.J., Barnes, J.R., Dijkman, R., Jores, J., Benarafa, C., Wentworth, D.E., Thiel, V., and Beer, M. (2021) SARS-CoV-2 spike D614G change enhances replication and transmission. Nature 592:7852, 122-127. (PubMed) (article)

Zimmer, G. (2021) Rhabdoviruses as vaccine vectors for veterinary pathogens. In: Viral Vectors in Veterinary Vaccine Development: A Textbook. Vanniasinkam, T., Tikoo, S.K., and Samal, S.K. (Eds.). Springer International Publishing, Cham, p. 141-148. (article)

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