In cooperation with leading internal and external partners we are identifying the mechanisms and correlates of protection against African Swine Fever Virus (ASFV). Using systems immunology and omics technologies—including bulk and single-cell transcriptomics, as well as adaptive immune receptor sequencing—we map the highly complex landscape of host responses to infection and vaccination. We develop pig-specific computational biology tools to decode the key innate and adaptive immune responses that drive either disease progression or protection. The knowledge gained is applied to understand the protective mechanisms of vaccines and develop next-generation, more effective ASF vaccines.
Funding:
- Horizon Europe ASFaVIP. Understanding performance characteristics of live attenuated vaccines for the prevention and control of African swine fever in wild boars and domestic pigs.
- Horizon Europe EUP AH&W. European Partnership on Animal Health and Welfare.
