Non-vector-borne transmission of Flaviviruses

Zika virus (ZIKV), a zoonotic emerging Flavivirus primarily transmitted by arthropods of the Aedes genus, is responsible for severe congenital and acquired neurological defects. Detection of ZIKV RNA in most body fluids as well as infections through sexual contact led to question the virus’ routes of infection. In order to study the relevance and mechanisms of non-vector borne transmission of ZIKV, we are using in vitro models based on epithelial and antigen-presenting cells.