Immune and stromal cell compartments interaction

Mesenchymal stem/stromal cells (MSCs) can be isolated from several tissues and have the property to differentiate into cells of the mesodermal lineage. While controversial, there is in vitro evidence that MSCs can transdifferentiate into cells originating from the endoderm and ectoderm. Because of this large panel of differentiation capability, MSCs are believed to play an important role in tissue homeostasis and repair. In addition to their regenerative capacity, MSCs have a potent immunomodulatory activity and are interacting with dendritic cells, macrophages, and T/B lymphocytes. We are dissecting interactions of MSCs and immune cells and the impact of virus infection on their plasticity.