The proinflammatory activity of the influenza virus neuraminidase

Sialic acids, which act as cellular receptor determinants for influenza viruses, play key roles in many physiological processes including regulation of the alternative pathway of complement activation by engaging factor H and control of inflammatory responses via sialic acid-binding immunoglobulin-like lectins (Siglecs) on lymphocytes. The influenza virus neuraminidase (NA) is a sialidase which plays a crucial role in virus release from infected cells. We aim at studying the role of NA in influenza virus pathogenicity, in particular its role in exaggerated inflammation and tissue damage.

Funding:

  • Swiss National Research Foundation (project starting in autumn 2016).