SRLV interactions with their target cells and the innate immune system
SRLV induce a poor interferon (IFN) response in infected cells. Moreover, SRLV are quite resistant to the antiviral effects of IFN and replicate unabatedly in cells treated with IFN and in a full antiviral state. We are at present investigating the molecular mechanisms of IFN non-induction/resistance in SRLV infections. (Collaboration with M. Schweizer, Group 'Viral infections of ruminants').