Miniorgans for studying host-pathogen interactions

Induced pluripotent stem (iPS) cell-derived organoids are 3D organ-like structures obtained by mimicking the organogenesis processes in vitro. Miniature organs derived from the three germ layers through iPS cells-controlled differentiation show remarkable cellular architecture complexity and functions similar to their in vivo counterparts. We are currently working towards the development of iPS cells-derived organoids from epithelia of selected mucosal surfaces as models to investigate host-pathogen interactions in an in vivo-like environment.